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簡要描述:動態(tài)足底觸覺儀是評估大鼠、小鼠足底對觸覺敏感性的測試設(shè)備
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品牌 | 其他品牌 | 產(chǎn)地類別 | 進口 |
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應(yīng)用領(lǐng)域 | 綜合 |
中國區(qū)總代理,高精度、自動化的疼痛感覺評估工具,專為小動物實驗設(shè)計。利用熱刺激技術(shù),在大小鼠足底施加可控溫度的熱刺激,通過記錄抬足潛伏期量化疼痛感知閾值,為疼痛模型建立、藥物鎮(zhèn)痛效果評估及理痛機制研究提供客觀、量化的數(shù)據(jù)支持。
型號:37550
主要特色
測試主機
測試主機顯示面板
· 便攜和易用移動的觸覺刺激器,配有剛性探針和可調(diào)節(jié)角度的鏡子;
· 十字孔板測試平臺;
電控型測試探針
十字測試網(wǎng)格
· 受試動物在鼠籠內(nèi)科自由活動;
· 操作人員將觸覺刺激器放置在動物爪子正下方,在反光鏡的幫助下定位硬絲;
A:剛性探針被自動抬高;
C:力度以預(yù)設(shè)施力速率增加,直到動物移除爪子或達到預(yù)設(shè)力度,自動停止加力;
力度分辨率 0.1g(0.5-5g),0.5g(5-50g)
力增加速率可調(diào)范圍 1-20s
數(shù)據(jù)的采集
· 測試主機可直觀顯示測試數(shù)據(jù),并對數(shù)據(jù)進行存儲;
· 數(shù)據(jù)可導(dǎo)出到電腦,或者使用專用U盾進行數(shù)據(jù)拷貝;
· 通信由基于CUB Data Acquisition Windows®的專用軟件包52050-10管理;
· 能夠?qū)嶒灁?shù)據(jù)傳送到電腦并使用常用軟件進行管理;
· 配備了存儲鍵,用于記錄回顧實驗數(shù)據(jù);
· 支持使用遠程網(wǎng)絡(luò)連接測試主機,對實驗參數(shù)進編輯;
參考文獻
1.Fri??i?, Jasna, et al. "The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts." Immunity 54.5 (2021):
1002-1021. doi:10.1016/j.immuni.2021.03.003
2.Boyd, Jacob T., et al. "Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions."
Nature metabolism 3.6 (2021): 762-773.doi:
3.Defaye, Manon, et al. "The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain." The Journal of clinical investigation 132.12 (2022).doi:
10.1172/JCI154317
4.Liu, Shijia, et al. "Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions." Neuron 110.5 (2022): 857-873. doi:10.1016/j.neuron.2021.11.029
5.Powell, Rasheen, et al. "Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior." Nature Communications 12.1 (2021): 5812.
10.1038/s41467-021-26100-6
6.Cheong, Hogyun, et al. "Sutureless neurorrhaphy system using a macrophage-polarizing in situ visible light-crosslinkable adhesive protein hydrogel for functional
nerve regeneration." Chemical Engineering Journal 445 (2022): 136641. doi:10.1016/j.cej.2022.136641
7.Llorca-Torralba, Meritxell, et al. "Pain and depression comorbidity causes asymmetric plasticity in the locus coeruleus neurons." Brain 145.1 (2022): 154-167. doi:
10.1093/brain/awab239
8.Sohn, Hee Su, et al. "Tolerogenic nanoparticles induce type II collagen?specific regulatory T cells and ameliorate osteoarthritis." Science Advances 8.47 (2022):
eabo5284.doi: 10.1126/sciadv.abo5284
9.Fotio, Yannick, et al. "NAAA-regulated lipid signaling governs the transition from acute to chronic pain." Science advances 7.43 (2021): eabi8834.doi:10.1126/sciadv.abi8834
10.Kolbinger, Anja, et al. "Eosinophil‐derived IL‐4 is necessary to establish the inflammatory structure in innate inflammation." EMBO Molecular Medicine 15.2
(2023): e16796.doi:
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