BodyCap的e-Celsius體溫測量膠囊是一款可連續(xù)監(jiān)測、記錄并無線傳輸核*心體溫信號的微型膠囊。

體溫膠囊經(jīng)口腔攝入進(jìn)入體內(nèi)，通過胃、腸道，由排出。膠囊自身具有記憶功能，測量對象無需佩戴任何監(jiān)測器而進(jìn)行無限制的測量。使用簡單方便，用于多個(gè)科研領(lǐng)域。我們還有動物的核心體溫膠囊。

外部溫度和環(huán)境濕度會將與物理力有關(guān)的熱應(yīng)力放大，人體體溫調(diào)節(jié)機(jī)制的飽和系統(tǒng)性地導(dǎo)致性能下降，并可迅速導(dǎo)致體溫過高。基于可攝取電子膠囊的e-Celsius Performance®解決方案可實(shí)現(xiàn)對核心體溫的連續(xù)監(jiān)測。系統(tǒng)能夠識別和傳輸溫度，并連續(xù)記錄人體的核*心溫度，在1米范圍之內(nèi)都可以收集到可靠的實(shí)驗(yàn)數(shù)據(jù)。

在運(yùn)行項(xiàng)目的應(yīng)用中：很多項(xiàng)目都具備測試條件，特別是有氧運(yùn)動為主的項(xiàng)目，如自行車，長跑，鐵人三項(xiàng)；也可應(yīng)用于橄欖球和跳水項(xiàng)目。

多種規(guī)格可供選擇，有專門的人體型號，也有多種用于實(shí)驗(yàn)室大鼠、小鼠、比格犬等動物的型號。

體溫膠囊的主要特點(diǎn)：

·體積小巧，食用方便，對機(jī)體無損害；

· 實(shí)時(shí)、連續(xù)、監(jiān)測；

· 無線無導(dǎo)管測量，測試對象亦無需實(shí)時(shí)佩戴監(jiān)測器，實(shí)現(xiàn)無限制測量方案；

· 膠囊內(nèi)置存儲記憶功能，可存儲多達(dá)2000組數(shù)據(jù)，無需擔(dān)心數(shù)據(jù)丟失；

· 監(jiān)測器可同時(shí)監(jiān)測3枚膠囊數(shù)據(jù)，且自身可多達(dá)7臺并聯(lián)，實(shí)現(xiàn)高通量測量；

主要技術(shù)參數(shù)：

· 人用體溫膠囊，經(jīng)口服攝入，通過消化道排泄，體內(nèi)時(shí)間1-2天（因人而異）

· 測量參數(shù)：測量溫度范圍25-45℃，精確度0.02℃，采樣頻率30Hz（可設(shè)定），內(nèi)部可存儲2000組數(shù)據(jù)；

· 傳輸參數(shù)：傳輸距離1m，傳輸頻率433Hz；

·規(guī)格參數(shù)：17.7*8.9mm，重1.7g，可存儲時(shí)間1年，開始使用后20天；

· 可同時(shí)監(jiān)測并顯示3枚膠囊傳輸數(shù)據(jù)，并可通過PC/MAC觀察分析；

· 每臺監(jiān)測器可存儲80000組數(shù)據(jù)；

主要應(yīng)用領(lǐng)域：

·體溫過低/高溫中暑預(yù)防：體溫測量降低低溫/高溫惡劣環(huán)境損害，或加強(qiáng)對發(fā)熱、寒戰(zhàn)等的感知；

·運(yùn)動熱身/恢復(fù)監(jiān)測：監(jiān)測人體鍛煉各階段體溫的變化，有助于判斷機(jī)體運(yùn)動技能；

·技能評估、優(yōu)化：用于評估機(jī)體體溫調(diào)節(jié)或心臟節(jié)律調(diào)節(jié)功能等；

·量化、預(yù)防、規(guī)避時(shí)差影響：監(jiān)測體溫晝夜節(jié)律變化，制定合理作息，從而規(guī)避時(shí)差影響等；

· 睡眠、晝夜節(jié)律和運(yùn)動表現(xiàn)分析：通過體溫變化反映機(jī)體睡眠、晝夜節(jié)律、運(yùn)動等規(guī)律。

參考文獻(xiàn)：

1. Michael Douglas Reed et al., (2019)“IL-17a promotes sociability in mouse models of neurodevelopmental disorders" Nature doi:10.1038/s41586-019-1843-6

2. Topilko T et al.,(2022) “ Edinger-Westphal peptidergic neurons enable maternal preparatory nesting" Neuron doi:10.1016/j.neuron.2022.01.012

3. NPJ Vaccines et al., (2022) “Safety and immunogenicity of four-segmented Rift Valley fever virus in the common marmoset" NPJ Vaccines DOI：10.1038/s41541-022-00476-y

4. Laperrousaz et al., (2018) “Lipoprotein Lipase Expression in Hypothalamus is involved in the Central Regulation of Thermogenesis and the Response to Cold Exposure" Frontiers in Endocrinology doi: 10.3389/fendo.2018.00103

5. Meyer et al., (2017) “Body Temperature Measurements for Metabolic Phenotyping in Mice" Frontiers in Endocrinology doi: 10.3389/fendo.2018.00103

6. Ru?ange et al., (2020) “Pre-warming before general anesthesia with iso?urane delays the onset of hypothermia in rats" PLoS One doi: 10.1371/journal.pone.0219722

7. Tattersall et al., (2016) “Novel energy-saving strategies to multiple stressors in birds: the ultradian regulation of body temperature" P Roy Soc B-Biol Sci doi: 10.1098/rspb.2022.0526 

8. Schulze et al., (2018) “Body temperature of bitches in the ?rst week after parturition measured by ingestible loggers" Reproduction in Domestic Animals doi:10.1111/rda.13330

9. Guisle et al., (2020) “Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature" Sleep doi:10.1093/sleep/zsz266

10. Thi Cuc Mai et al.,(2021) “Low-Level Radiofrequency Exposure Induces Vasoconstriction in Rats." Sci Rep DOI：10.1002/bem.22350 

eCelsius

11. Mart Toots et al., (2019) “Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia Sci Transl Med "doi:10.1016/j.xcrm.2021.100408

12. van Maanen L et al., (2019) “Core body temperature speeds up temporal processing and choice behavior under deadlines" Sci Rep doi:10.1038/s41598-019-46073-3

13. Marine Alhammoud et al.,(2021)“Thermoregulation and shivering responses in elite alpine skiers" Eur J Sport Sci doi:10.1080/17461391.2020.1754470

14. Christopher J. Stevens et al.,(2018) “Effect of two-weeks endurance training wearing additional clothing in a temperate outdoor environment on performance and physiology in the heat " Temperature (Austin) doi:10.1080/23328940.2018.1474672

   

    

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